1/21/2023 0 Comments Calibre academy ein number![]() Most cases of Hirschsprung disease are diagnosed in the newborn period. ![]() A transition zone is present, where a marked change in caliber occurs, with the dilated normal colon above and the narrowed aganglionic colon below. The disease results in decreased motility in the affected bowel segment, lack of propagation of peristaltic waves into the aganglionic colon, and abnormal or absent relaxation of this segment and of the internal anal sphincter. The ganglion cells help coordinate and facilitate bowel relaxation, and if they are absent, the bowel becomes spastic and results in distal intestinal obstruction. Hirschsprung disease (HD) is characterized by the absence of myenteric and submucosal ganglion cells (Auerbach and Meissner plexuses) along a variable length of the distal GI tract. ![]()
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